منابع مشابه
DNA damage recognition and repair by 3-methyladenine DNA glycosylase I (TAG).
DNA glycosylases help maintain the genome by excising chemically modified bases from DNA. Escherichia coli 3-methyladenine DNA glycosylase I (TAG) specifically catalyzes the removal of the cytotoxic lesion 3-methyladenine (3mA). The molecular basis for the enzymatic recognition and removal of 3mA from DNA is currently a matter of speculation, in part owing to the lack of a structure of a 3mA-sp...
متن کاملRepair of topoisomerase I-mediated DNA damage.
Yves Pommier*, Juana Barcelo, V. Ashutosh Rao, Olivier Sordet, Andrew G. Jobson, Laurent Thibaut, Zheyong Miao, Jennifer Seiler, Hongliang Zhang, Christophe Marchand, Keli Agama and Christophe Redon Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, DHHS * To whom reprint requests should be addressed, Bldg. 37, Rm. 5068, N...
متن کاملRecruitment of DNA methyltransferase I to DNA repair sites.
In mammalian cells, the replication of genetic and epigenetic information is directly coupled; however, little is known about the maintenance of epigenetic information in DNA repair. Using a laser microirradiation system to introduce DNA lesions at defined subnuclear sites, we tested whether the major DNA methyltransferase (Dnmt1) or one of the two de novo methyltransferases (Dnmt3a, Dnmt3b) ar...
متن کاملDNA-Repair Capacity in Down\'s Syndrome
Down's syndrome (DS) is the most common chromosomal abnormality in human. Subjects with DS are known to be peridisposed to develop leukemia. The molecular basis of the association between DS and leukemia is unknown. The unscheduled DNA synthesis (UDS) test measure the ability of DNA-repair in mammalian cells after excision of a stretch of DNA containing the region of damage induced by chemical ...
متن کاملA novel single-stranded DNA-specific 3′–5′ exonuclease, Thermus thermophilus exonuclease I, is involved in several DNA repair pathways
Single-stranded DNA (ssDNA)-specific exonucleases (ssExos) are expected to be involved in a variety of DNA repair pathways corresponding to their cleavage polarities; however, the relationship between the cleavage polarity and the respective DNA repair pathways is only partially understood. To understand the cellular function of ssExos in DNA repair better, genes encoding ssExos were disrupted ...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 1984
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.9.supplement_s9